Peptide modification via salts is a way to change to properties of the API to make it more advantageous to the desired release profile. If a longer release profile is desired, a hydrophobic salt can increase the dissolution time of an API. If better water solubility is desired, a hydrophilic salt can be added. Salts can be used to improve the stability, bioavailability, and dissolution properties of the target API.
Salts improve bioavailability, stability, manufacturability, and patient compliance
Peptide counter ions significantly affect the pharmaceutical properties of a drug for small molecules, peptides and proteins
Peptide salts were selected to alter the dissolution profile of the target molecule
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